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NCI Dictionary of Cancer Terms

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anti-VEGFR-2 fully human monoclonal antibody IMC-1121B  listen  (AN-tee … ful-ee HYOO-mun MAH-noh-KLOH-nul AN-tee-BAH-dee …)

  A substance being studied in the treatment of several types of cancer, including stomach, esophageal, breast, urinary tract, and non-small cell lung cancer. Anti-VEGFR-2 fully human monoclonal antibody IMC-1121B binds to receptors for a protein called vascular endothelial growth factor (VEGF), which may be found on some types of cancer cells. This may prevent the growth of new blood vessels that tumors need to grow. Anti-VEGFR-2 fully human monoclonal antibody IMC-1121B is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called IMC-1121B and ramucirumab.