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NCI Dictionary of Cancer Terms

atypical squamous cells of undetermined significance  listen  (AY-TIH-pih-kul SKWAY-mus sels … UN-deh-TER-mind sig-NIH-fih-kunts)

  A finding of abnormal cells in the tissue that lines the outer part of the cervix. Atypical squamous cells of undetermined significance is the most common abnormal finding in a Pap test. It may be a sign of infection with certain types of human papillomavirus (HPV). It may also be a sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as an HPV test, may be needed. Also called ASC-US and ASCUS.