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NCI Dictionary of Cancer Terms


DHFR inhibitor  listen  (… in-HIH-bih-ter)

  A substance that can build up in cancer cells and block them from using folate. Folate is a nutrient that rapidly dividing cells need to make DNA. Blocking folate use helps keep cancer cells from growing and may kill them. Some DHFR inhibitors are used to treat cancer. A DHFR inhibitor is a type of antifolate. Also called dihydrofolate reductase inhibitor.