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NCI Drug Dictionary

NCI Drug Dictionary

  

tarenflurbil 
An orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. Tarenflurbil does not inhibit the enzyme cyclo-oxygenase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:R-flurbiprofen
US brand name:Flurizan
Code names:E-7869
MPC-7869
Chemical structure:(R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid