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The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||BAY 43-9006 |
BAY 43-9006 Tosylate Salt
|US brand name:||Nexavar|
|Code name:||BAY 54-9085|
|Chemical structures:||2-pyridinecarboxamide, 4-[4-[[[[4-chloro-3- trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl- |
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate tosylate