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NCI Drug Dictionary


A monoclonal immunoglobulin G1 antibody with potential antineoplastic activity. Siplizumab binds to CD2, a specific receptor found in T cells and NK cells, thereby triggering a host immune response that results in lysis of CD2+ cells, selective suppression of the immune system, and control of activated T cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:anti-CD2 monoclonal antibody
Code name:MEDI-507