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NCI Drug Dictionary

NCI Drug Dictionary

  

paclitaxel poliglumex 
The agent paclitaxel linked to a biodegradable, water-soluble polyglutamate polymer with antineoplastic properties. The polyglutamate residue increases the water solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. Paclitaxel promotes microtubule assembly and prevents microtubule depolymerization, thus interfering with normal mitosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:paclitaxel-polyglutamate polymer
polyglutamate paclitaxel
polyglutamic acid paclitaxel
Poly-L-Glutamic acid-Paclitaxel Conjugate
US brand name:Xyotax
Abbreviation:PG-TXL
Code name:CT-2103