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NCI Drug Dictionary

  

ziv-aflibercept  Patient Information
A protein comprised of segments of the extracellular domains of human vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their cell receptors. Disruption of the binding of VEGFs to their cell receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:aflibercept
vascular endothelial growth factor trap
VEGF Trap
VEGF Trap R1R2
US brand name:Zaltrap