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NCI Drug Dictionary


A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Nimustine Hydrochloride
pimustine hydrochloride
US brand name:ACNU 50
Foreign brand name:Nidran
Chemical structure:N'-[4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea