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fotemustine
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Foreign brand name: | | Muphoran | |
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| Code name: | | S 10036 | |
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| Chemical structures: | | [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate | |
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