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NCI Drug Dictionary


recombinant interleukin-3 
A recombinant form of interleukin-3, a cytokine produced by activated T-cells and mast cells involved in intercellular communication, hematopoiesis, and inflammation. IL-3 binds and activates specific receptors on hematopoietic cells and in the nervous system, triggering expression of specific genes via the Ras signaling pathway and through Jak2 activation. This agent stimulates the proliferation of pluripotent hematopoietic progenitor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:eosinophil-mast cell growth factor
erythrocyte burst-promoting factor
mast cell colony-stimulating factor
multipotential colony-stimulating factor
Code name:ILE-964