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NCI Drug Dictionary


A synthetic derivative of inosinic acid with antiretroviral and immunomodulatory activities. Rintatolimod acts through a number of pathways to stimulate the antiviral activity of the immune system. This agent stimulates interferon production; activates the oligoadenylate synthase-RNase L pathway; stimulates natural killer cell activity; and acts as a non-mitogenic stimulator of the immune system. Rintatolimod also inhibits replication of the human immunodeficiency virus (HIV) in vitro. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Ampligen
Abbreviation:poly(I):poly(C12U) RNA
Chemical structure:poly(inosinic acid) poly(cytidylic(12), uridylic)acid