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NCI Drug Dictionary


chromomycin A3 
A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus. Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis. This agent is used as a fluorescent chromosome dye. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:aburamycin B
antibiotic B 599
Chemical structures:3B-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D
olivomycin D, 3B-O-(4-O-Acetyl-2, 6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl)-7-methyl- (9CI)