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NCI Drug Dictionary

NCI Drug Dictionary

  

metoprine 
A diaminopyrimidine folate antagonist with potential antineoplastic activity. Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:DDMP
Code name:BW 197U