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NCI Drug Dictionary


inosine dialdehyde 
A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name:Wy-5321
Chemical structures:9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)
9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI)
diglycolaldehyde, alpha-(hydroxymethyl)-.alpha.'-(6-hydroxy-9H-purin-9-yl)