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NCI Drug Dictionary


estramustine phosphate sodium 
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:estramustine Phosphate
US brand name:Emcyt
Foreign brand name:Estracyt
Code names:Leo-299
Ro 22-2296/000
Chemical structures:estra-1,3,5(10)-triene-3,17-diol(17(beta))-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate
estramustine 17-(dihydrogenphosphate) disodium salt