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NCI Drug Dictionary


A murine monoclonal IgG2a antibody to tumor-associated epithelial cell adhesion molecule (EpCAM, or 17-1A) antigen. Edrecolomab attaches to EpCAM, a human cell surface glycoprotein that is found on normal epithelial cells and some tumor cells, such as those of colon and breast carcinomas. Upon binding, this agent recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:monoclonal antibody 17-1A
Foreign brand name:Panorex
Abbreviation:MOAB 17-1A