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NCI Drug Dictionary


A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:2-nitro-imidazole derivative
Code name:SR-2508
Chemical structures:1H-imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
2-nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-