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NCI Drug Dictionary

  

omacetaxine mepesuccinate  Patient Information
A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:homoharringtonine
US brand name:Synribo
Abbreviation:HHT
Code name:CGX-635
Chemical structures:1-[(1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H- cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-yl] 4-methyl (2R)-2- hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)
cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI)