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NCI Drug Dictionary

NCI Drug Dictionary

  

zorubicin hydrochloride 
A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:benzoyl hydrazone daunorubicin
daunorubicin benzoylhydrazone hydrochloride
rubidazone
Foreign brand name:Zorubicine
Abbreviation:RBZ
Code name:RP-22050
Chemical structures:(2S-cis)-benzoic acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
benzoic acid hydrazide 3-hydrazone with daunorubicin