NCI Drug Dictionary
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A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||benzoyl hydrazone daunorubicin |
daunorubicin benzoylhydrazone hydrochloride
|Foreign brand name:||Zorubicine|
|Chemical structures:||(2S-cis)-benzoic acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide |
benzoic acid hydrazide 3-hydrazone with daunorubicin