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NCI Drug Dictionary

NCI Drug Dictionary

  

trimetrexate glucuronate 
A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:TMQ
US brand name:Neutrexin
Abbreviation:TMTX
Chemical structure:2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate