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NCI Drug Dictionary

  

zalcitabine 
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:dideoxycytidine
US brand name:Hivid
Abbreviation:ddC
Chemical structure:2',3'-dideoxycytidine