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NCI Drug Dictionary

NCI Drug Dictionary

  

L-leucovorin 
The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Calcium levoleucovorin
Levofolinate
Levofolinate calcium
Levofolinic acid
Levoleucovorin
US brand name:Isovorin
Foreign brand name:Elvorine, Isovorin, Levofolene, Levorin
Abbreviation:L-CF
Code name:CL-307,782
Chemical structure:L-5-Formyltetrahydrofolate