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NCI Drug Dictionary


A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:23-L-leucine colony-stimulating factor 2
granulocyte macrophage colony-stimulating factor
US brand names:Leukine
rhu GM-CFS