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NCI Drug Dictionary


chloroquinoxaline sulfonamide 
A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Chemical structure:benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-