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NCI Drug Dictionary

NCI Drug Dictionary

  

gemcitabine hydrochloride  Patient Information
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:difluorodeoxycytidine hydrochloride
gemcitabine
US brand name:Gemzar
Abbreviations:dFdC
dFdCyd
Code name:LY-188011
Chemical structures:1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride
2'-deoxy-2',2'-difluorocytidine hydrochloride
2'deoxy-2',2'-difluorocytidine hydrochloride