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NCI Drug Dictionary

NCI Drug Dictionary

  

recombinant interleukin-6 
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, antiinflammatory, proproliferative and proangiogenic activities. IL-6 binds to its receptor (IL-6R), activating a receptor-CD130 receptor complex; the CD130 portion of the complex is a signal transduction protein that activates JAK kinases and ras-mediated signaling pathways, which in turn activate downstream signaling pathways, resulting in the activation of various transcription factors (STAT, ELK-1, NF-IL-6, etc.) and gene transcription. The physiological effects of IL-6 are complex and varied and include hematopoietic, pyrogenic and thermogenic, proinflammatory, antiinflammatory, proproliferative (anti-apoptotic), and angiogenic effects. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:B-cell differentiation factor-2
B-cell stimulatory factor 2
hepatocyte-stimulating factor
hybridoma growth factor
plasmacytoma growth factor
recombinant IFN beta 2
US brand name:Sigosix
Abbreviations:HSF
IL-6