NCI Drug Dictionary
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A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Kynacyte|
|Chemical structures:||2-amino-1,3-dihydroxyoctadecane |