In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

safingol 
A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:sphinganine
US brand name:Kynacyte
Chemical structures:2-amino-1,3-dihydroxyoctadecane
L-threo-dihydrosphingosine