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NCI Drug Dictionary


shark cartilage extract AE-941 
A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Neovastat
Foreign brand name:Neovastat
Code name:AE-941