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NCI Drug Dictionary

  

monoclonal antibody Ch14.18 
A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Monoclonal antibody Ch14.18 binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ch14.18
MOAB Ch14.18
Abbreviation:MOAB Ch14.18