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NCI Drug Dictionary


A humanized recombinant monoclonal antibody directed against CD33, a cell surface antigen found on myeloid leukemia blasts and early hematopoietic progenitor cells. Lintuzumab stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing CD33, resulting in a decrease in tumor burden. The humanized version of this monoclonal antibody exhibits less immunogenicity and improved binding affinity compared to its murine counterpart. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
HuG1-M195 monoclonal antibody
Hu-M195 monoclonal antibody
Abbreviations:MOAB HuG1-M195