NCI Drug Dictionary
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A sulfated polysaccharide isolated from various Arthrobacter bacterial species. Possessing potential antiangiogenic and antineoplastic properties, tecogalan binds to basic fibroblast growth factor (bFGF), thereby preventing bFGF from binding to its receptors. Disruption of this receptor binding results in the inhibition of bFGF-stimulated endothelial cell growth, proliferation, and migration. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||Sulfated Polysaccharide Tecogalan DS-4152|