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NCI Drug Dictionary


recombinant interleukin-12 
A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:cytotoxic lymphocyte maturation factor
natural killer cell stimulatory factor
recombinant human interleukin-12 (IL-12) cytokine
Code name:Ro 24-7472