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NCI Drug Dictionary

NCI Drug Dictionary

  

nolatrexed dihydrochloride 
The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Nolatrexed
nolatrexed hydrochloride
US brand name:Thymitaq
Code name:AG337
Chemical structure:3,4-dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline Dihydrochloride