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NCI Drug Dictionary


samarium Sm 153 lexidronam pentasodium 
The pentasodium salt of samarium Sm 153 lexidronam, a therapeutic agent consisting of a medium energy beta- and gamma-emitting radioisotope, samarium Sm 153, and a teraphosphonate chelator, ethylenediaminetetramethylene phosphonic acid (EDTMP). The chelator moiety of samarium Sm 153 lexidronam associates with hydroxyapatite crystals concentrated in areas of bone turnover, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to osteoblastic bone metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:samarium Sm 153 lexidronam
Samarium-153 EDTMP
Sm 153 lexidronam pentasodium
US brand name:Quadramet
Sm-153 EDTMP