NCI Drug Dictionary
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A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||cytarabine liposome |
|US brand name:||DepoCyt|
|Foreign brand name:||DepoCyte|
|Code name:||DTC 101|