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NCI Drug Dictionary


A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid. This leads to an accumulation of acetaldehyde that produces a variety of very unpleasant symptoms referred to as the disulfiram-alcohol reaction. This reaction includes , but is not limited to, flushing, headache, respiratory difficulty, nausea,vomiting, sweating, thirst, chest pain, tachycardia, blurred vision and hypotension. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Antabuse
Chemical structures:bis(diethylthiocarbamoyl) disulfide
tetraethylthioperoxydicarbonic diamide
tetraethylthiuram disulfide