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NCI Drug Dictionary

NCI Drug Dictionary

  

recombinant platelet factor 4 
A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CXC-chemokine PF-4
CXCL4
platelet factor 4
recombinant human platelet factor 4
Abbreviation:rPF4
Acronym:rhPF4