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NCI Drug Dictionary


A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code names:KT6149
KW 2149
Chemical structure:7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C