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NCI Drug Dictionary


IL-2 plasmid DNA/lipid complex 
An immunotherapeutic agent consisting of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), in a 5:1 ratio. Due to the lipophilic nature of this cation liposome complex, this gene transfer system may improve the efficiency of introducing the IL-2 gene into the cells, thereby increasing the production of IL-2 and inducing an immune response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:IL-2 plasmid DNA/DMRIE/DOPE lipid complex
interleukin-2 DNA/lipid complex
plasmid DNA IL-2 lipid complex
US brand name:Leuvectin
Code name:VCL-1102