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NCI Drug Dictionary


A fully humanized monoclonal antibody directed against the CD20 antigen with potential antineoplastic activity. Following binding, veltuzumab triggers complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) in cells that overexpress CD20. CD20 antigen is a hydrophobic transmembrane protein located on pre-B and mature B lymphocytes. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:monoclonal antibody hA20
Abbreviation:MOAB hA20