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NCI Drug Dictionary


ISIS 5132 
A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:c-RAF Antisense
ISIS 5132/CGP69846A
RAF-IK Antisense ODN
Code names:CGP 69846A