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NCI Drug Dictionary


A synthetic derivative of dithio-ethane sulfonate with uroprotective properties. In the kidney, dimesna undergoes reduction to the free thiol compound, mesna, which reacts chemically with the urotoxic ifosfamide metabolites acrolein and 4-hydroxy-ifosfamide, resulting in their detoxification. This agent also inhibits cyclophosphamide-induced hemorrhagic cystitis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:mesna disulfide
US brand name:Tavocept
Code name:BNP7787
Chemical structure:2,2'-dithio-bis-ethanesulfonate, disodium salt