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NCI Drug Dictionary


PSA prostate cancer vaccine 
A peptide vaccine containing the prostate specific antigen (PSA) with potential antineoplastic activity. PSA, a glycoprotein secreted by prostatic epithelial and ductal cells, is overexpressed in prostate cancer cells and is used as a tumor marker for both diagnosis and treatment evaluation. Vaccination with PSA peptide vaccine may produce anti-PSA antibodies as well as elicit a cytotoxic T-cell (CTL) response against prostate cancer cells expressing this antigen, thereby decreasing tumor cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:OncoVax-PR
Abbreviation:PSA VAC