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NCI Drug Dictionary

NCI Drug Dictionary

  

tinidazole 
A 5-nitroimidazole derivative with antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group in turn is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names:Fasigyn
Tindamax
Foreign brand name:Simplotan
Abbreviation:TDZ