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NCI Drug Dictionary


vaccinia-tyrosinase vaccine 
A vaccine consisting of recombinant vaccinia virus, based on the modified vaccinia virus Ankara (MVA), that encodes the melanoma-associated antigen tyrosinase. Vaccination with vaccinia-tyrosinase may stimulate the host immune system to mount a cytotoxic T-cell response against tumor cells expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the synthesis of the melanin precursor L-3,4-dihydroxyphenylalanine (L-DOPA). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:rV-TYR Vaccine