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NCI Drug Dictionary

NCI Drug Dictionary

  

defibrotide 
A polydeoxyribonucleotide with antithrombotic, thrombolytic, and fibrinolytic properties. Defibrotide induces the release of prostaglandin 12 and reduces the expression of adhesion molecules on endothelial cells, thereby interfering with platelet and leukocyte adhesion to the endothelium. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)