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NCI Drug Dictionary


tucotuzumab celmoleukin 
A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. The humanized monoclonal antibody moiety of tucotuzumab celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of this fusion protein may stimulate a cytotoxic T-cell antitumor immune response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:huKS-IL2 fusion protein
KSA-Interleukin-2 Fusion Protein
Code name:EMD 273066