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NCI Drug Dictionary

  

atomoxetine hydrochloride 
The hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft; the effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Strattera
Chemical structures:(-)-N -methyl-3-phenyl-3-(o-tolyloxy)-propylamine hydrochloride
(-)-N-methyl-gamma(2-methylphenoxy)benzenepropamine Hydrochloride