In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary


ixabepilone (oral) 
An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:oral ixabepilone